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Fundamental physics

Single DNA molecule stretching force

Single DNA molecule stretching force is the force required to extend a single DNA strand under controlled laboratory conditions.

Also known as: DNA stretching force, single molecule DNA force

How big is it?

5 × 10⁻¹¹ N · representative stretching force

Representative stretching force · representative
Typical recorded range: 1 × 10⁻¹² N to 1 × 10⁻¹⁰ N.

Scale illustration of the force stretching a single DNA molecule, showing the recorded representative stretching force.
Recorded representative stretching force: 5 × 10⁻¹¹ N.

A little perspective

Single DNA molecule stretching force vs Gravitational attraction between two one-kilogram masses one metre apart: weight comparison

The gravitational attraction between two one-kilogram masses one metre apart is about 1.34 times the force stretching a single DNA molecule.

Scale

FORCE

Single DNA molecule stretching force

Single DNA molecule stretching force is the force required to extend a single DNA strand under controlled laboratory conditions.

5 × 10⁻¹¹ NRepresentative stretching force
0
Gravitational attraction between two one-kilogram masses one metre apart

This is the gravitational force acting between two one-kilogram objects placed one metre apart in a vacuum.

6.7 × 10⁻¹¹ NForce
0
Bar length measures force in newtons. Mass and local gravity determine weight.
Measurements, assumptions & sources +

Single DNA molecule stretching force

Representative stretching force: 5 × 10⁻¹¹ N; representative; range 1 × 10⁻¹² N–1 × 10⁻¹⁰ N.

A representative 50 pN single-molecule force in the DNA stretching regime. Measured force depends on construct, contour state, buffer, temperature and pulling protocol; the molecular image is schematic.

NIST — DNA stretching measurements

The marked representative stretching force is calibrated. Unmeasured illustration details are representative.

Gravitational attraction between two one-kilogram masses one metre apart

Force: 6.7 × 10⁻¹¹ N; derived calculation.

Newtonian point-mass force between two 1 kg masses separated centre to centre by 1 m. It is calculated, not a direct force measurement.

Calculated for two point masses from the CODATA gravitational constant; the displayed value is rounded and inherits G's measurement uncertainty.

NIST — 2022 CODATA fundamental constants

The marked force is calibrated. Unmeasured illustration details are representative.

Use the visual comparison to explore its scale, then check the measurements and sources.

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Why this measurement?

Why we use 5 × 10⁻¹¹ N

We compare the force stretching a single DNA molecule. This is a representative comparison value; individual specimens or conditions can vary. The recorded range is 1 × 10⁻¹² N to 1 × 10⁻¹⁰ N.

A representative 50 pN single-molecule force in the DNA stretching regime. Measured force depends on construct, contour state, buffer, temperature and pulling protocol; the molecular image is schematic.

The picture identifies the subject; the diagram compares the recorded values. How calibrated comparisons work →

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Recorded properties

Dimensions and measurements

PropertySelected valueRecorded rangeBasis
5 × 10⁻¹¹ N1 × 10⁻¹² N to 1 × 10⁻¹⁰ Nrepresentative

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Sources and method

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